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Alpha-1D adrenergic receptor

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionAug 25, 2026
Entity authorityQ17710464 ↗
Source-derived summary

The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.

Ligands

Many α1 receptor ligands are non-selective for receptor subtypes.

Antagonists

A-315456

BMY 7378 (also α2C antagonist)

Domesticine

Cyclazosin (slight α1C selectivity)

Tamsulosin (roughly equal affinity for α1A)

See also

Adrenergic receptor

References

Further reading

External links

Human ADRA1A genome location and ADRA1A gene details page in the UCSC Genome Browser.

Human ADRA1D genome location and ADRA1D gene details page in the UCSC Genome Browser.

Editorial summary

This brief starts where responsible research should: with the source description of “Alpha-1D adrenergic receptor” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current 155-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where Alpha-1D, adrenergic and receptor can be independently traced.
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Why this record matters

The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Aug 25, 2026. The linked authority identifier is Q17710464. None of the 0 selected statements returned an explicit reference.

Critical limits

Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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Source & attribution

This entry incorporates text from “Alpha-1D adrenergic receptor” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.