5′-Methylthioadenosine
chemical compound
5′-Methylthioadenosine is S-methyl derivative of the adenosine. It is an intermediate in the methylthioadenosine (MTA) cycle, also known as the methionine salvage pathway, that is universal to aerobic organisms.
Formation
The pervasive cofactor S-adenosyl methionine (SAM) is the precursor to 5′-methylthioadenosine. The sulfonium group in SAM can cleave in three ways, one involves loss of CH2CH2CH(NH3+)CO2−, generating the title compound.
History
In 1912, an adenine nucleoside was isolated by Hunter et al. from yeast that were grown without phosphorus or sulfur. Later in 1925, that substance was shown by Levene and Sobotkal to be adenylthiomethylpentose.
In 1936, Nakahara et al. did experiments on rats that suggested that vitamin L2 deficiency inhibits the ability of female rats for lactation. In 1942, they identified vitamin L2 to be adenylthiomethylpentose.
“5′-Methylthioadenosine” enters the record as chemical compound. Crown Archives preserves that source wording while asking what -Methylthioadenosine, chemical and compound can confirm, complicate or overturn.
Why this record matters
“5′-Methylthioadenosine” is worth following because a concise public description often conceals a longer documentary argument. Here, -Methylthioadenosine, chemical and compound provides the most credible route into that argument.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Aug 15, 2026. The linked authority identifier is Q3599216. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1912, 1925, 1936 and 1942.
Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.
- Current terminology
- Classification context
- Finding cited technical literature
Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.
Three-step research path
- Establish the record: confirm the title “5′-Methylthioadenosine”, its source revision and the description used here.
- Expand the search: follow 5′-Methylthioadenosine primary sources, 5′-Methylthioadenosine archive and -Methylthioadenosine research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “5′-Methylthioadenosine”?
- Which observation, specimen, dataset or publication supports the account?
- Has classification or technical consensus changed since the cited source?
Search terms from this dossier
This entry incorporates text from “5′-Methylthioadenosine” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.