Adenine deaminase
InterPro Family
In enzymology, an adenine deaminase (EC 3.5.4.2) is an enzyme that catalyzes the chemical reaction
adenine + H2O
⇌
{\displaystyle \rightleftharpoons }
hypoxanthine + NH3
Thus, the two substrates of this enzyme are adenine and H2O, whereas its two products are hypoxanthine and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenine aminohydrolase. Other names in common use include adenase, adenine aminase, and ADase. This enzyme participates in purine metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 2ICS.
References
Blauch M, Koch FC, Hane ME (1939). "A study of xanthine oxidase of rat blood". J. Biol. Chem.
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This entry incorporates text from “Adenine deaminase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.