Ketorolac
chemical compound
Ketorolac, sold under the brand names Toradol, Acular and Sprix, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used for the short-term treatment of moderate to severe pain. Its use is generally limited to no more than five days because extended treatment increases the risk of serious adverse effects. It can be taken by mouth, by nose, by injection into a vein or muscle, and as eye drops. Effects begin within an hour and last for up to eight hours. Ketorolac also has antipyretic (fever-reducing) properties.
Common side effects include sleepiness, dizziness, abdominal pain, swelling, and nausea. Serious side effects may include stomach bleeding, kidney failure, heart attacks, bronchospasm, heart failure, and anaphylaxis. Use is not recommended during the last part of pregnancy or during breastfeeding. Ketorolac works by blocking cyclooxygenase 1 and 2 (COX1 and COX2), thereby decreasing production of prostaglandins.
Ketorolac was patented in 1976 and approved for medical use in 1989.
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