Acetrizoic acid
chemical compound
Acetrizoic acid is a pharmaceutical drug that was used as an iodinated contrast medium for X-ray imaging. It was applied in form of its salt, sodium acetrizoate, but is no longer in clinical use.
Chemistry and mechanism of action
The substance has high osmolality and is water-soluble. The three iodine atoms in the molecule readily absorb X-rays and are therefore responsible for its usability as a contrast medium.
History
Acetrizoate was developed by V.H. Wallingford of Mallinckrodt, and introduced in 1950; it was employed as a contrast agent for several radiographic studies, including pyelography, angiography of the brain, carotid arteries and the aorta, and cholecystography. It was soon found to be highly toxic to the kidneys and nervous system—work urging caution in its administration was published as early as 1959, after reports of adverse reactions ranging from hypersensitivity to brain damage—and was eventually replaced by other agents with higher efficacy and lower toxicity, such as sodium diatrizoate, a closely related compound.
Trade names
Trade names include Urokon, Triurol and Salpix, as well as Gastrografina and Urografina in Portugal.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Sep 17, 2026. The linked authority identifier is Q3604494. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1950 and 1959.
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This entry incorporates text from “Acetrizoic acid” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.