Vasopressin
hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP
Mammalian vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure.
A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress.
Vasopressin induces differentiation of stem cells into cardiomyocytes and promotes heart muscle homeostasis.
It has a very short half-life, between 16 and 24 minutes.
Physiology
Function
Vasopressin regulates the tonicity of body fluids. It is released from the posterior pituitary in response to hypertonicity and causes the kidneys to reabsorb solute-free water and return it to the circulation from the tubules of the nephron, thus returning the tonicity of the body fluids toward normal.
“Vasopressin” enters the record as hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. Crown Archives preserves that source wording while asking what Vasopressin, hormone and synthesized can confirm, complicate or overturn.
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Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Aug 10, 2026. The linked authority identifier is Q21124841. The Library of Congress control number is sh85142404. None of the 1 selected statements returned an explicit reference.
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