Inositol nicotinate
chemical compound
Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements.
Mechanism of action
When ingested, inositol nicotinate breaks down into inositol and niacin. The niacin component helps widen blood vessels (vasodilation), lowers blood lipid levels (including cholesterol), and inhibits a protein involved in blood clotting.
Uses
Inositol nicotinate is used to treat blood circulation problems, including:
Raynaud's phenomenon
Intermittent claudication
Some research shows it can improve symptoms of Raynaud's phenomenon over several weeks. However, its effectiveness in treating other conditions like:
High cholesterol
High blood pressure
Leg pain during exercise (due to poor circulation)
remains unclear, with studies producing mixed results.
Other proposed uses, such as for:
Migraines
Psoriasis
Restless legs syndrome
have insufficient supporting evidence.
Side effects
Inositol nicotinate is generally safe when taken by mouth, but possible side effects include:
Stomach upset
Intestinal gas
Nausea
Liver damage (similar to other niacin products)
It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin.
Precautions
Inositol nicotinate should be used with caution in individuals with certain conditions:
Diabetes: May raise blood sugar levels. Diabetic patients should monitor their blood sugar levels closely.
“Inositol nicotinate” enters the record as chemical compound. Crown Archives preserves that source wording while asking what Inositol, nicotinate and chemical can confirm, complicate or overturn.
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