Vonoprazan
chemical compound
Vonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication. Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
It was approved in Japan in February 2015, and in Russia in April 2021. Vonoprazan was approved for medical use in the United States in November 2023. Co-packaged combinations of vonoprazan with amoxicillin and vonoprazan with amoxicillin and clarithromycin are available.
Medical uses
Vonoprazan is indicated for healing of all grades of erosive esophagitis and relief of heartburn associated with erosive esophagitis in adults; to maintain healing of all grades of erosive esophagitis and relief of heartburn associated with erosive esophagitis in adults; in combination with amoxicillin and clarithromycin for the treatment of Helicobacter pylori (H. pylori) infection in adults; in combination with amoxicillin for the treatment of H. pylori infection in adults.
In July 2024, the indication was expanded in the US to include non-erosive gastroesophageal reflux disease.
Adverse effects
The most common side effects are constipation, diarrhea, enlarged feeling of abdomen, nausea, rash, and edema.
Long-term use may lead to vitamin B12 deficiency, hypomagnesemia, and fundic gland polyps.
Society and culture
Names
Vonoprazan is the international nonproprietary name (INN).
This brief starts where responsible research should: with the source description of “Vonoprazan” as chemical compound. Everything that follows is an evidence route, not borrowed authority.
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The subject matters to the science & nature register because the source frames it as chemical compound. Its deeper value depends on whether names, dates, institutions and citations support that framing.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Feb 10, 2026. The linked authority identifier is Q27887191. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2015, 2021, 2023 and 2024.
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This entry incorporates text from “Vonoprazan” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.