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Aquaporin-5

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionSep 8, 2026
Entity authorityQ17831317 ↗
Source-derived summary

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene.

Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.

AQP-5 features a homotetrameric structure embedded in the cell membrane with the center of each monomer acting as a water pore. Each monomer structure is a transmembrane protein which have an asparagine–proline–alanine (NPA) hydrophobic residue embedded in the membrane of the cell. The NPA residue plays a role in water and solute permeability across the membrane of the cell.

References

Further reading

External links

AQP5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Editorial summary

Begin with the source’s own compact description: “Aquaporin-5” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through Aquaporin-5, protein-coding and gene, not as a finished interpretation.

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The phrase “protein-coding gene in the species Homo sapiens” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.

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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Sep 8, 2026. The linked authority identifier is Q17831317. None of the 0 selected statements returned an explicit reference.

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Source & attribution

This entry incorporates text from “Aquaporin-5” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.