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AP4S1

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionSep 15, 2026
Entity authorityQ18036164 ↗
Source-derived summary

AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene.

Function

The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1, this gene).

Clinical relevance

Deficiency of AP-4 leads to childhood-onset hereditary spastic paraplegia and it is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.

See also

AP2 adaptor complex

References

External links

Human AP4S1 genome location and AP4S1 gene details page in the UCSC Genome Browser.

Editorial summary

The public source identifies “AP4S1” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around AP4S1, protein-coding and gene.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current 111-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its value is orientation rather than verdict, with AP4S1, protein-coding and gene providing the first useful test.
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A short description can identify a subject without explaining its stakes. For “AP4S1”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.

Evidence profile

Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Sep 15, 2026. The linked authority identifier is Q18036164. None of the 0 selected statements returned an explicit reference.

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Source & attribution

This entry incorporates text from “AP4S1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.