STRAD beta
protein-coding gene in the species Homo sapiens
STE20-related kinase adapter protein beta (or STRAD beta) is an enzyme that in humans is encoded by the STRADB gene (previously ALS2CR2).
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.
Interactions
ALS2CR2 has been shown to interact with XIAP.
References
External links
Human STRADB genome location and STRADB gene details page in the UCSC Genome Browser.
This brief starts where responsible research should: with the source description of “STRAD beta” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 10, 2026. The linked authority identifier is Q4652433. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “STRAD beta” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.