Adrogolide
chemical compound
Adrogolide (INNTooltip International Nonproprietary Name; developmental code names A-93431, ABT-431, and DAS-431), also known as adrogolide hydrochloride (USANTooltip United States Adopted Name) in the case of the hydrochloride salt, is a dopamine D1-like receptor agonist which was under development for the treatment of Parkinson's disease, cognition disorders, and cocaine-related disorders but was never marketed.
It is a chemically stable and rapidly converted diacetate ester prodrug of the highly selective dopamine D1 and D5 receptor full agonist A-86929. The effects of adrogolide and A-86929 in animals and humans have been studied. Side effects of adrogolide in humans included injection site reactions, asthenia, headache, nausea, vomiting, postural hypotension, vasodilation, and dizziness.
Adrogolide was under development by Abbott Laboratories and DrugAbuse Sciences. It reached phase 2 clinical trials for Parkinson's disease prior to the discontinuation of its development in 2001. The drug is said to have been the first extensively characterized dopamine D1 receptor full agonist.
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