6-Hydroxy-DMT
chemical compound
6-Hydroxy-DMT, or 6-HO-DMT, also known as 6-hydroxy-N,N-dimethyltryptamine, is a serotonin receptor modulator of the tryptamine family related to the psychedelic drug dimethyltryptamine (DMT). It is a major metabolite of DMT in rodents but a minor metabolite of DMT in humans. The drug is the 6-hydroxy analogue of DMT and is a positional isomer of bufotenin (5-HO-DMT) and psilocin (4-HO-DMT).
Use and effects
6-Hydroxy-DMT was completely inactive in terms of psychoactive and autonomic effects at doses of 0.75 to 1 mg/kg (~53–70 mg for a 70-kb person) by intramuscular injection in humans. The drug was said to be indistinguishable from placebo. Conversely, DMT produced strong hallucinogenic effects at the same doses.
Pharmacology
Although it was inactive as a psychedelic in humans, 6-hydroxy-DMT has been found to produce pharmacological effects in animals, albeit with diminished potency compared to dimethyltryptamine (DMT). As examples, in terms of behavioral effects, 6-hydroxy-DMT was ≥3-fold less potent in rats, >10-fold less potent in cats, and 3-fold less potent in monkeys. It was suggested by Richard Glennon and colleagues that the reduced activity of 6-hydroxy-DMT may be due to its greater hydrophilicity and reduced ability to penetrate the blood–brain barrier analogously to the case of bufotenin.
Subsequent research assessed 6-hydroxy-DMT at the serotonin receptors in vitro.
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