3-Methoxy-4-methylamphetamine
chemical compound
3-Methoxy-4-methylamphetamine (MMA) is an entactogen and psychedelic drug of the phenethylamine and amphetamine classes. It was first synthesized in 1970 and was encountered as a street drug in Italy in the same decade. MMA was largely forgotten until being reassayed by David E. Nichols as a non-neurotoxic MDMA analogue in 1991, and has subsequently been sold as a designer drug on the internet since the late 2000s.
In animal studies, MMA fully substitutes for MDMA and MBDB, partially substitutes for LSD, and does not substitute for amphetamine in rodent drug discrimination tests. However, in another study, MMA fully substituted for dextroamphetamine in such tests. Additionally, it has been shown to be a potent and highly selective serotonin releasing agent (SSRA) and does not produce serotonergic neurotoxicity in rodents. These data appear to confer a profile of MMA as a selective serotonin releasing agent (SSRA) and serotonin 5-HT2A receptor agonist.
In humans, MMA has been reported to be hallucinogenic, "quite dypshoric", and long-lasting. The active doses have been reported to be 40 to 60 mg. Capsules containing 140 mg have been encountered as a designer drug in Italy in the 1980s.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Feb 17, 2026. The linked authority identifier is Q2813117. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1970 and 1991.
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This entry incorporates text from “3-Methoxy-4-methylamphetamine” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.