4-Methoxyphenethylamine
pharmaceutical compound
4-Methoxyphenethylamine (4-MPEA), also known as O-methyltyramine, is a drug of the phenethylamine family. It is one of the methoxyphenethylamine positional isomers. Along with mescaline (3,4,5-trimethoxyphenethylamine), 4-MPEA is naturally occurring in Lophophora williamsii (peyote) and other cacti. It has also been found in the flowering plant Erica lusitanica, as well as in human urine.
Use and effects
4-MPEA was inactive in humans at a dose of up to 400 mg.
Pharmacology
4-MPEA has been found to act as a serotonin releasing agent and norepinephrine releasing agent in vitro. It has also been found to be very weakly active as a dopamine reuptake inhibitor, whereas dopamine release induction does not appear to have been assessed. The drug showed very low affinity for the serotonin receptors in the rat stomach fundus strip (A2 = 7,940 nM). 4-MPEA is a very-low-potency partial agonist of the human trace amine-associated receptor 1 (TAAR1) (EC50Tooltip half-maximal effective concentration = 5,980 nM; EmaxTooltip maximal efficacy = 106%).
In animals, 4-MPEA produced catalepsy, catatonia, a hypokinetic rigid syndrome, and indirect sympathomimetic effects, among other effects.
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This entry incorporates text from “4-Methoxyphenethylamine” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.