4-Fluoroephedrine
chemical compound
4-Fluoroephedrine (4-FEP) is a "novel psychoactive substance" and substituted β-hydroxyamphetamine derivative related to ephedrine.
Pharmacology
Similarly to other amphetamines, 4-fluoroephedrine acts as a monoamine reuptake inhibitor and monoamine releasing agent. It specifically acts as a selective norepinephrine releasing agent. In contrast to many other amphetamines, but similarly to most cathinones, 4-fluoroephedrine lacks affinity for the human trace amine-associated receptor 1 (hTAAR1).
Chemistry
4-Fluoroephedrine, also known as 4-fluoro-β-hydroxy-N-methylamphetamine, is a substituted phenethylamine, amphetamine, and β-hydroxyamphetamine derivative. It is the 4-fluoro analogue of ephedrine.
The synthesis of 4-fluoroephedrine has been described.
It can serve as a precursor in the synthesis of 4-fluoromethamphetamine (4-FMA).
The predicted log P (XLogP3) of 4-fluoroephedrine is 1.0. For comparison, the predicted log P of ephedrine is 0.9.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Dec 21, 2025. The linked authority identifier is Q27278210. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “4-Fluoroephedrine” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.