3-Methoxyphenethylamine
chemical compound
3-Methoxyphenethylamine (3-MPEA) is a drug of the phenethylamine family. It is one of the methoxyphenethylamine positional isomers.
The drug showed very low affinity for the serotonin receptors in the rat stomach fundus strip (A2 = 1,290 nM). 3-MPEA is a low-potency partial agonist of the human trace amine-associated receptor 1 (TAAR1) (EC50Tooltip half-maximal effective concentration = 1,444 nM; EmaxTooltip maximal efficacy = 73%). The effects of 3-MPEA in humans have not been reported and are unknown.
3-MPEA was first described in the scientific literature by at least 1943. It was studied at Edgewood Arsenal and received the code name EA-1302. The drug was included as an entry in Alexander Shulgin's 2011 book The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds.
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