Bromopyruvic acid
chemical compound
Bromopyruvic acid is the organic compound with the formula BrCH2COCO2H. This colorless solid is the brominated derivative of pyruvic acid. It bears structural similarity to lactic acid and pyruvic acid. It has been investigated as a metabolic poison and an anticancer agent. Like other α-bromoketones, it is a strong alkylating agent.
Research
Bromopyruvic acid attracts attention in the biomedical research capacity through its potential to inhibit tyrosine phosphatases. Activity of such phosphatases is required for the activation of platelets, especially in a process called venous thromboembolism, a major cause of mortality during gastrointestinal cancer. Bromopyruvic-mediated inhibition of tyrosine phosphatases can counteract such thromboembolism and is investigated as novel angel to combat cancer-associated mortality. The pyruvate transporter system can be used to deliver bromopyruvate inside trypanosomal cells. Once intracellular, the primary target of 3BP is glyceraldehyde-3-phosphate dehydrogenase, which is highly sensitive to inhibition by bromopyruvate. The pyruvate transporter system, which is known to be overexpressed in cancer cells, was later identified to be a monocarboxylate transporter called monocarboxylate transporter 1.
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This entry incorporates text from “Bromopyruvic acid” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.