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N-hydroxy-2-acetamidofluorene reductase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionFeb 22, 2026
Entity authorityQ3575015 ↗
Source-derived summary

N-hydroxy-2-acetamidofluorene reductase (EC 1.7.1.12) is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are hydroxyacetylaminofluorene, reduced nicotinamide adenine dinucleotide (NADH), and a proton. Its products are 2-acetylaminofluorene, oxidised NAD+, and water. The enzyme can use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-acetamidofluorene:NAD(P)+ oxidoreductase. Other names in common use include N-hydroxy-2-acetylaminofluorene reductase, and NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase.

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Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current 92-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. For this dossier, N-hydroxy-2-acetamidofluorene, reductase and class is the immediate research focus.
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This entry incorporates text from “N-hydroxy-2-acetamidofluorene reductase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.