Glutaryl-7-aminocephalosporanic-acid acylase
class of enzymes
Glutaryl-7-aminocephalosporanic-acid acylase (EC 3.5.1.93) is an enzyme characterised from a Pseudomonas species that catalyzes the hydrolysis of the cephalosporin antibiotic, glutaryl-7-aminocephalosporanic acid, to the parent 7-ACA and glutaric acid:
The structure of several of these enzymes have been determined. An immobilised version of the enzyme has been produced as a means of making 7-ACA for the manufacture of other derivatives.
This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase. Other names in use include 7beta-(4-carboxybutanamido)cephalosporanic acid acylase, cephalosporin C acylase, glutaryl-7-ACA acylase, CA, GCA, GA, cephalosporin acylase, glutaryl-7-aminocephalosporanic acid acylase, and GL-7-ACA acylase.
The public source identifies “Glutaryl-7-aminocephalosporanic-acid acylase” as class of enzymes. This brief keeps that definition visible, then builds a research path around Glutaryl-7-aminocephalosporanic-acid, acylase and class.
Why this record matters
A short description can identify a subject without explaining its stakes. For “Glutaryl-7-aminocephalosporanic-acid acylase”, the useful work is to connect “class of enzymes” to the records capable of establishing context and consequence.
Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Sep 25, 2026. The linked authority identifier is Q5572457. None of the 0 selected statements returned an explicit reference.
A concise general-reference account can conceal disagreements about scope, terminology or the weight assigned to individual sources. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “Glutaryl-7-aminocephalosporanic-acid acylase”, its source revision and the description used here.
- Expand the search: follow Glutaryl-7-aminocephalosporanic-acid acylase primary sources, Glutaryl-7-aminocephalosporanic-acid acylase archive and Glutaryl-7-aminocephalosporanic-acid research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “Glutaryl-7-aminocephalosporanic-acid acylase”?
- Which institution is responsible for the underlying evidence?
- What terminology or title could unlock a more precise catalogue search?
Search terms from this dossier
This entry incorporates text from “Glutaryl-7-aminocephalosporanic-acid acylase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.