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Prostaglandin-A1 Delta-isomerase

class of enzymes

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 19, 2025
Entity authorityQ7250939 ↗
Source-derived summary

In enzymology, a Prostaglandin-A1 Δ-isomerase (EC 5.3.3.9) is an enzyme that catalyzes the chemical reaction

(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate

⇌

{\displaystyle \rightleftharpoons }

(13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate

Hence, this enzyme has one substrate, (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate (Prostaglandin A1 or PGA1), and one product, (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate (Prostaglandin C1).

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate Delta10-Delta11-isomerase. This enzyme is also called prostaglandin A isomerase.

References

Polet H, Levine L (1975). "Metabolism of prostaglandins E, A, and C in serum". J. Biol. Chem. 250 (2): 351–7. doi:10.1016/S0021-9258(19)41907-8.

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“Prostaglandin-A1 Delta-isomerase” enters the record as class of enzymes. Crown Archives preserves that source wording while asking what Prostaglandin-A1, Delta-isomerase and class can confirm, complicate or overturn.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current lead gives the account dated anchors—1975, 1016—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Prostaglandin-A1, Delta-isomerase and class.
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The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Jul 19, 2025. The linked authority identifier is Q7250939. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1975 and 1016.

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This entry incorporates text from “Prostaglandin-A1 Delta-isomerase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.